Trisomy 21 (1 in 700 newborns) is the most common trisomy at the time of birth and causes Down Syndrome, which is associated with mild to moderate intellectual disabilities and may also lead to digestive issues and congenital heart defects.

Trisomy 18 (1 in 5,000 newborns) causes Edwards syndrome, which is associated with a high rate of miscarriage. Infants born with Edwards syndrome may have various medical conditions and a shortened lifespan.

Trisomy 13 (1 in 16,000 newborns) causes Patau syndrome, which is associated with a high rate of miscarriage. Infants with trisomy 13 usually have severe congenital heart defects and other medical conditions. Survival beyond the first year is rare.

Sex chromosome conditions The sex chromosomes (X and Y) determine the gender of every individual. X and Y chromosome-associated conditions occur when there is a missing, extra or incomplete copy of one of the sex chromosomes. The most commonly observed abnormal combinations are XXX, XYY, XXY (Klinefelter syndrome), and monosomy X (Turner syndrome). There is significant variability in the severity of the associated conditions, but most individuals have mild, if any, physical or behavioural symptoms

Down Syndrome Trisomy - 21

1	2	3	4	5	6	7	8
9	10	11	12	13	14	15	16
17	18	19	20	21	22	XX	XY

100% Safe, High Sensitivity 99.9%, High Specificity 99.8%
Genoma: expert in Next Generation Sequencing (NGS)

Foetal DNA is detectable from the 5th week of gestation. Its concentration increases during the following weeks and disappears after childbirth. The amount of foetal DNA present as from the 10th week of gestation is sufficient to guarantee the high specificity and sensitivity of Tranquility.

Next Generation Sequencing (NGS) or "massively parallel DNA sequencing", one of the most modern genetic analysis technologies available today, is used to count the number of copies of chromosomes. Then, a calculation algorithm determines if there are too many or too few copies of these chromosomes present.

After extraction and sequencing of DNA from the maternal blood, the algorithm counts the number of copies of chromosomes and ensures that you get the most accurate results.

The likelihood of having a false positive or a false negative result is extremely low. This accuracy is of uttermost importance for you. This way, in most of the cases the result of the Tranquility test will avoid the amniocentesis, a procedure with a risk of miscarriage for the pregnant woman.

The latter test is usually carried out during weeks 15-20 of pregnancy. A needle is used to extract a sample of the amniotic fluid that surrounds the foetus (the developing baby) in the womb (uterus). Amniotic fluid contains cells shed from the foetus that can be examined and tested for a number of diseases. The procedure is quite invasive (involves going into the body) and has an associated risk of miscarriage (the loss of pregnancy). This risk is estimated to be around 1%.

Every year, thousands of miscarriages are provoked by amniocentesis, resulting in the loss of a mother's baby that are often not affected by any disorder!

Is Tranquility safe compared to traditional screening tests?
Tranquility uses a simple, risk-free, single blood draw from your arm. Unlike with amniocentesis, there is no risk for the baby.

Is Tranquility easy to perform compared to traditional screening tests?
Your blood sample can be drawn at your doctor’s office, as early as from the 10th week of gestation (12 weeks for twin pregnancies).

Is Tranquility accurate compared to traditional screening tests?
Tranquility provides reliable answers. Tranquility is much more accurate than traditional methods: Tranquility ensures a sensitivity 99.9% for trisomy 21 (vs. 70% for traditional methods).

Is Tranquility accurate compared to other NIPT?
Tranquility has only < 0.09% no call rate. This means that in > 99.9% of the time, the test will be able to generate the analysis report. This means there is no need to additional tests or doctor visits.

What kind of technology is used to perform Tranquility test?
Tranquility is performed using the most advanced, complete and comprehensive technology based on MPS (Massive parralele Sequencing); and the whole genome analysis.

Can I trust Genoma?
Our quality requirements follows the most stringent international quality standards to ensure the most accurate and fastest results.

Is Tranquility fast compared to traditional screening tests?
The report is faster than traditional methods; you will receive the results in 5 to 7 working days from reception at the laboratory (unless further analysis are required).

Is Tranquility faster than other NIPT?
Tranquility delivers the fastest results. Genoma selected the most advanced technology meaning that results will be ready in the shortest possible time.

Have Tranquility results been proven?
The performance of Tranquility has been evaluated in major scientific studies led by world renowned medical research and educational institutions. The study findings were published in well established medical and scientific journals.

Can I talk to someone to get more information about Tranquility?
Our specialist team and customer care department will always be there to help you in your own language with any questions you may have about the Tranquility test or our other products and any further information you might need.

Can I know the sex of my future baby?
If you want to know the sex of your baby, Tranquility can also tell you if your foetus carries XX or XY chromosomes.